Pathophysiology of exercise capacity after heart transplantation

Time course of exercise capacity, skeletal and respiratory muscle performance after heart-lung transplantation.

Recipients of heart-lung transplantation (HLT) show reduced exercise capacity due to several pre- and postsurgical factors. The aim of this study was to evaluate the time course of exercise capacity, and skeletal and respiratory muscle performance in 11 patients (5 females and 6 males; age (mean +/- SD) 38 +/- 13 yrs) undergoing HLT. All of the patients were admitted to our institution for a re...

Relationship between impaired pulmonary diffusion and cardiopulmonary exercise capacity after heart transplantation.

STUDY OBJECTIVES Diffusion impairment and reduced performance in cardiopulmonary exercise testing (CPX) have been found in patients after heart transplantation. The pathogenesis of these abnormalities is unclear. In particular, the contribution of pulmonary interstitial changes has not yet been verified. DESIGN We analyzed pulmonary function tests, high-resolution CT (HRCT), echocardiography,...

Adrenergic Receptor Polymorphism and Maximal Exercise Capacity after Orthotopic Heart Transplantation

BACKGROUND Maximal exercise capacity after heart transplantion (HTx) is reduced to the 50-70% level of healthy controls when assessed by cardiopulmonary exercise testing (CPET) despite of normal left ventricular function of the donor heart. This study investigates the role of donor heart β1 and β2- adrenergic receptor (AR) polymorphisms for maximal exercise capacity after orthotopic HTx. METH...

Determinants of peak aerobic capacity after heart transplantation.

The search for predictive factors of peak aerobic capacity after heart transplantation is an interesting challenge. Although heart transplantation vastly improves the physical capacity of the heart recipients, they still have a reduced peak aerobic capacity (Vo 2) compared to healthy sedentary people. Heart recipients' aerobic capacity is, of course, related to biometric characteristics (predic...

Capacity for exercise after denervation of the heart.